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A NEW EFFICIENT SYNTHESIS OF ω-AMINOALKYLIDENE-1,1-BISPHOSPHONATE TETRAETHYLESTERS
17
Citations
7
References
1998
Year
Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicineAbstract BisphosphonatesOrganic ChemistryOriginal SynthesisIntermediate HydroxyalkylidenebisphosphonatesChemistryHeterocycle ChemistryPharmacologyPharmaceutical ChemistrySynthetic ChemistryEnantioselective SynthesisDrug Discovery
Abstract Bisphosphonates are interesting therapeutic agents in the management of bone diseases and since several years our laboratory has been developing the chemistry of 1,1-bisphosphonates. This paper describes an original synthesis of two aminoalkylidenebisphosphonates by first preparing the intermediate hydroxyalkylidenebisphosphonates which are transformed into amines via the azides.
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