Concepedia

Smooth Muscle Cholesterol Enables BK β1 Subunit-Mediated Channel Inhibition and Subsequent Vasoconstriction Evoked by Alcohol

Anna N. Bukiya, Thirumalini Vaithianathan, Guruprasad Kuntamallappanavar, Maria Asuncion‐Chin, Alex M. Dopico

Arteriosclerosis Thrombosis and Vascular Biology · 2011 · 52 citations · 36 references

DOIFull text

Open access

Abstract

VSMC cholesterol and BK β1 are both required for ethanol inhibition of BK and the resulting cerebral artery constriction, with health-related implications for manipulating cholesterol levels in alcohol-induced cerebrovascular disease.

References

36

Regulation of Arterial Tone by Activation of Calcium-Dependent Potassium Channels

Joseph E. Brayden, Mark T. Nelson · Science · 1992 · 932 citations

, , +21

Vasoregulation by the β1 subunit of the calcium-activated potassium channel

Robert Brenner, Guillermo J. Pérez, Adrian D. Bonev et al. · Nature · 2000 · 799 citations

, , +8

Functional role of the β subunit of high conductance calcium-activated potassium channels

Owen B. McManus, Lisa M. H. Helms, Leo J. Pallanck et al. · Neuron · 1995 · 464 citations · Full text

, , +14

Cholesterol as Modulator of Receptor Function

Gerald Gimpl, Katja Bürger, Falk Fahrenholz · Biochemistry · 1997 · 456 citations

Presynaptic Ca<sup>2+</sup>-Activated K<sup>+</sup>Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release

Hua Hu, Sorush Chavoshy, Ning Gu et al. · Journal of Neuroscience · 2001 · 333 citations · Full text