1,1-Bis(3′-Indolyl)-1-(<i>p</i>-Substitutedphenyl)methanes Induce Apoptosis and Inhibit Renal Cell Carcinoma Growth

Abstract

DIM-C-pPhtBu and related compounds are cytotoxic to renal cancer cells and activate multiple proapoptotic and growth-inhibitory pathways. The results coupled with in vivo anticancer activity show the potential of DIM-C-pPhtBu and related C-DIMs for clinical treatment of renal adenocarcinoma.