European Journal of Organic Chemistry · 2011 · 28 citations · 44 references
Natural SciencesChemistryCatalysisGreen ChemistryOrganic ChemistryCatalyst DesignCatalyst SynthesisCatalytic MaterialsGreen CatalysisOrganic SynthesisSupported CatalystsChiral Catalyst DesignEnantioselective CatalysisEnantioselective Catalyst DesignEnantioselective SynthesisGreen Catalyst DesignGreen Solvent SelectionHeterogeneous Catalyst DesignHeterogeneous Catalyst Preparation
Abstract Polystyrene‐supported chiral 2,2′‐methylenebis[(4 S )‐4‐ tert ‐butyl‐2‐oxazoline] is a promising heterogeneous catalyst for the enantioselective Henry reaction of nitromethane with substituted benzaldehydes. The process is carried out in ethanol as a green solvent, and the corresponding chiral β‐nitroalcohols are obtained in 56–95 % yield with 49–88 % ee .
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The Henry reaction: recent examples
Frederick A. Luzzio · Tetrahedron · 2001 · 746 citations
Hiroaki Sasai, Takeyuki Suzuki, Shigeru Arai et al. · Journal of the American Chemical Society · 1992 · 604 citations
Catalytic asymmetric Henry reaction
Joshodeep Boruwa, Naminita Gogoi, Partha Pratim Saikia et al. · Tetrahedron Asymmetry · 2006 · 422 citations