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THE EFFECT OF METHYLTHIOURACIL ON THE OXYGEN CONSUMPTION OF THE THYROID, LIVER AND KIDNEYS
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1948
Year
NeuroendocrinologyPathologyBasal MetabolismAbundant LiteratureLiver And KidneysThe ThyroidOxidative StressReproductive EndocrinologyToxicologyHuman MetabolismThyroid PhysiologyHealth SciencesHypoxia (Medicine)EndocrinologyPharmacologyPhysiologyThyroid DiseaseThyroid DisordersThyroid HormoneMetabolismMedicineEndocrine Disease
An abundant literature has made its appearance as a result of the observations that the sulphonamides, thiocarbamides, and thiouracils provoked hyperplasia of the thyroid (Astwood, 1943, 1944; Kennedy, 1942; Mackenzie and Mackenzie, 1943, 1944; Mackenzie, Mackenzie and McCollum, 1941; Richter and Clisby, 1942), and that the basal metabolism falls in proportion as the hyperplasia increases (Astwood, Sullivan, Bissell and Tyslowitz, 1943). Investigations have been chiefly directed on analyzing more in detail the mechanism of the effects of these substances. The hyperplasia of the thyroid proved to be conditioned by an increased excretion of thyrotropin, which in its turn was due to a decrease in the formation of the thyroid hormone, whereby the checking effect of the hormone on the anterior lobe of the hypophysis declined (Astwood and Bissell, 1944; Astwood, Sullivan, Bissell and Tyslowitz, 1943; Higgens and Ingle, 1946).