Secondary Structure Dependent Self‐Assembly of β‐Peptides into Nanosized Fibrils and Membranes

Abstract

In control: The secondary structure dependent self-assembly of β-peptides in solution proves that natural biopolymers are not unique in their highly structured conformational behavior. Stereochemically controlled secondary structural units of β-peptide strands and helices intrinsically self-associate into pleated-sheet sandwiches (see picture) and helix-bundle membranes, respectively.