Recovery of Spermatogenesis by High Dose Gonadotropin-Releasing Hormone Analogue Treatment in Rat Cryptorchid Testis after Orchiopexy

Abstract

Administering the high dose Gn-RH agonist leuprorelin acetate after orchiopexy greatly enhanced the recovery of spermatogenesis in rats. This finding is in accordance with other recent reports that treatment with Gn-RH analogues promotes the regeneration of once damaged spermatogenesis. On the other hand, these findings may cause one to question supplementation therapy now used in regular practice to boys with cryptorchidism.