Silicon in synthesis. Methoxymethyltrimethylsilane, a new reagent for reductive nucleophilic acylation

Abstract

Lithium methoxy(trimethylsilyl)methylide (6), prepared by deprotonation of methoxymethyltrimethyl-silane (3) using s-butyl-lithium reacts with ketones and aldehydes to give adducts (7b)–(9b) that can be converted into aldehydes.