Wound-Induced HB-EGF Ectodomain Shedding and EGFR Activation in Corneal Epithelial Cells

Abstract

HB-EGF released on wounding acts as an autocrine-paracrine EGFR ligand. HB-EGF shedding and EGFR activation represent a critical event during corneal epithelial wound healing, suggesting a possible manipulation of wound healing during the early phases.