Differential Effects of Chlorthalidone<i>Versus</i>Spironolactone on Muscle Sympathetic Nerve Activity in Hypertensive Patients

Abstract

Our data suggest that chlorthalidone, the first-line drug therapy for hypertension, causes persistent activation of sympathetic nervous system and insulin resistance in hypertensive patients. These side effects, however, are avoided by spironolactone despite similar reduction in BP.