Rapid desensitization of somatodendritic 5‐HT_1Areceptors by chronic administration of the high‐efficacy 5‐HT_1Aagonist, F13714: a microdialysis study in the rat

Abstract

Rat somatodendritic 5-HT(1A) receptors controlling hippocampal 5-HT release were rapidly desensitized by chronic activation with a high-efficacy 5-HT(1A) agonist, but not by chronic activation with a partial agonist. Thus, rapid 5-HT(1A) autoreceptor desensitization by high-efficacy agonists may accelerate the onset of the therapeutic effects of antidepressants.