Colistin Methanesulfonate against Multidrug-Resistant <i>Acinetobacter baumannii</i> in an In Vitro Pharmacodynamic Model

Abstract

Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.