Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling

Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α

Robert A. Campbell, Poornima Bhat‐Nakshatri, Nikhil Patel et al. · Journal of Biological Chemistry · 2001 · 968 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

Hans-Guido Wendel, Elisa de Stanchina, Jordan S. Fridman et al. · Nature · 2004 · 947 citations

Medicine, Cancer Biology, Oncology +14

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

Aimee D. Kohn, Fumito Takeuchi, Richard A. Roth · Journal of Biological Chemistry · 1996 · 474 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

Gizeh Pérez‐Tenorio, Olle Stål · British Journal of Cancer · 2002 · 393 citations · Full text

Medicine, Cell Biology, Oncology +17

Inhibition of mTOR Activity Restores Tamoxifen Response in Breast Cancer Cells with Aberrant Akt Activity

Linda A. deGraffenried, William E. Friedrichs, Douglas Russell et al. · Clinical Cancer Research · 2004 · 387 citations

Medicine, Oncology, Pharmacology +16