Asymmetric Inverse‐Electron‐Demand Hetero‐Diels–Alder Reaction of Six‐membered Cyclic Ketones: An Enamine/Metal Lewis Acid Bifunctional Approach

Abstract

On demand: The first example of the title reaction involving cyclic ketones and β,γ-unsaturated α-ketoesters has been achieved using the novel enamine/metal Lewis acid bifunctional catalysis (see scheme; Tf=trifluoromethanesulfonyl). Enones with both electron-withdrawing and electron-donating groups at the γ position reacted smoothly with cyclohexanone affording the products in excellent chemo- and enantioselectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.