High‐Capacity Hierarchically Imprinted Polymer Beads for Protein Recognition and Capture

Abstract

Leaving an imprint: Hierarchical protein imprinting starting from wide-pore silica modified with a submonolayer of adsorbed protein (IgG or HSA) leads to an inverse polymeric replica of the silica template that features highly accessible protein-complementary binding sites (see picture). The resulting poly(acrylamide) beads (PIgG or PHSA) feature high binding capacities and can be used to selectively capture the proteins HSA and IgG from blood serum. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.