Increased Synthesis of Prostaglandins in the Guinea Pig Following Scalding Injury

Abstract

Abstract The urinary excretion in guinea pigs of the major urinary metabolite of prostaglandins E 1 and E 2 , viz 5β,7α‐dihydroxy‐11‐ketotetranor‐prostanoic acid, was increased 5–9 fold following scalding injury. Lipid extracts of homogenates of scalded guinea pig skin contained 20–40 times more smooth muscle stimulating activity than did extracts of non‐scalded skin. Prostaglandins (mainly PGE 2 and PGF 2α ) were responsible for about 80% of this activity.