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Synthesis of oligodeoxyribonucleotides by a continuous-flow, solid-phase method using phosphotriester intermediates
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1982
Year
Supramolecular AssemblyEngineeringMolecular BiologyPolymersDna NanotechnologyEfficient Solid-phase SynthesisPolymer ChemistryBiochemistryPhosphotriester IntermediatesOligonucleotideBiopolymersMolecular EngineeringBiomolecular EngineeringSolid-phase MethodNatural SciencesSelf-assemblySynthetic BiologyContinuous-flow Assembly ApparatusSynthetic ChemistryPolymer Synthesis
A new composite polydimethylacrylacrylamide–kieselguhr support has been used in a continuous-flow assembly apparatus for the efficient solid-phase synthesis of an undeca- and a heptadeca-deoxyribonucleotide using phosphotriester intermediates.