KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

Abstract

We report that KLF2 substantially enhances antioxidant activity of Nrf2 by increasing its nuclear localization and activation. The synergistic activity of these two transcription factors forms a major contribution to the shear stress-elicited transcriptome in endothelial cells.