Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized <i><scp>G</scp>inkgo biloba</i> leaf extracts to rats via different routes of administration

Abstract

Unlike the significant systemic exposure levels, the levels of cerebral exposure to the flavonols and terpene lactones are low. The elimination kinetic differences between the two classes of ginkgo compounds influence their relative systemic exposure levels. The information gained is relevant to linking ginkgo administration to the medicinal effects.