Protein Science · 2003 · 38 citations · 16 references
Life SciencesBiochemistryBiophysicsProtein FoldingStructural BiologyStructural BiophysicsFolding Energy LandscapesFolding KineticsMacromolecular FoldingProtein DynamicsProtein Folding ThermodynamicsProtein StructureFolding PathwaysMelting TemperatureMisfolding KineticsMolecular Dynamics Of FoldingProtein Folding Free Energy LandscapeProtein Folding LandscapesProtein Folding SimulationsTemperature Dependence Of Folding
Proteins fold in a time range of microseconds to minutes despite the large amount of possible conformers. Molecular dynamics simulations of a three-stranded antiparallel beta-sheet peptide (for a total of 12.6 microsec and 72 folding events) show that at the melting temperature the unfolded state ensemble contains many more conformers than those sampled during a folding event.
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