Concepedia

Publication | Open Access

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans

DOIFull Paper Access

29

Citations

40

References

2012

Year

Alison Seed, Rhoda E. Kuc, Janet J. Maguire, Christopher Hillier, Fiona Johnston, Hans Essers, Hanka J. de Voogd, John J.V. McMurray, Anthony P. Davenport
Life Sciences

Abstract

SLV-306 leads to inhibition of both NEP and ECE in humans. Simultaneous augmentation of ANP and inhibition of ET-1 production is of potential therapeutic benefit in cardiovascular disease.

References

YearCitations

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