Transmission of New Bovine Prion to Mice

Abstract

We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrP res ). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrP res molecular features distinct from BSE.