Concepedia

Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor–α Inhibitors

Russell D. Bradford, April C. Pettit, Patty W. Wright, Mark J. Mulligan, Larry W. Moreland, David McLain, John W. Gnann, Karen C. Bloch

Clinical Infectious Diseases · 2009 · 81 citations · 15 references

DOIFull text

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Concepts

Abstract

We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.

References

15

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TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Shen‐Ying Zhang, Emmanuelle Jouanguy, Sophie Ugolini et al. · Science · 2007 · 1.1K citations

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Diagnosis of Herpes Simplex Encephalitis: Application of Polymerase Chain Reaction to Cerebrospinal Fluid from Brain-Biopsied Patients and Correlation with Disease

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Safety and Efficacy of High-Dose Intravenous Acyclovir in the Management of Neonatal Herpes Simplex Virus Infections

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Risk of Herpes Zoster in Patients With Rheumatoid Arthritis Treated With Anti–TNF-α Agents

Anja Strangfeld · JAMA · 2009 · 543 citations

, , +15