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EFFECTS OF SHORT-TERM ADMINISTRATION OF LARGE DOSES OF HUMAN GROWTH HORMONE ON CARBOHYDRATE METABOLISM IN ADULT, NON-DIABETIC, HYPOPHYSECTOMIZED WOMEN; STUDIES WITH 14C-LABELLED GLUCOSE
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1962
Year
NutritionPeripheral DisposalHuman GrowthHypophysectomized WomenGynecologyReproductive EndocrinologyMetabolic SyndromeHealth SciencesDiabetes ManagementGrowth HormoneDiabetes ComplicationsEndocrinologyGlycemic ResponseNitrogen RetentionHuman Growth HormoneDiabetesPhysiologyDiabetes MellitusMetabolismMedicine
ABSTRACT Five adult, non-diabetic, hypophysectomized women were given human growth hormone (HGH) in doses of 10–20 mg/d for 2–3 days (total dose 30–60 mg). HGH induced nitrogen retention as well as fasting – and excessive postprandial – hyperglycaemia and glycosuria. These changes disappeared when HGH-treatment was stopped. The findings were interpreted as demonstrating that the development of »idiohypophyseal« diabetes mellitus in human subjects is possible. Studies with 14 C-labelled glucose in these subjects showed that the turnover rate of glucose was decreased by HGH, and that the absolute values for peripheral disposal of glucose were unchanged in three patients, decreased in one and transitorily decreased in the fifth. Since the blood glucose level increased during HGH, the results of the 14 C-glucose studies were taken as evidence that peripheral glucose metabolism is depressed by HGH in man.