MR diffusion imaging of cerebral infarction in humans.

TLDR

The study used MR diffusion imaging to examine water diffusion changes in cerebral infarction patients. ADC diffusion maps were generated for 15 patients and compared with conventional T2‑weighted images to assess local water mobility. ADC maps revealed heterogeneous diffusion within infarcts, varying even among lesions of the same age, and showed a gradual increase in diffusion coefficient over the first days post‑stroke, highlighting diffusion imaging’s potential to elucidate infarct evolution.

Abstract

PURPOSE MR diffusion imaging was performed to investigate changes in water diffusion in patients with cerebral infarction. METHODS Diffusion maps of the apparent diffusion coefficient (ADC) were created to show local water mobility in the brain tissue in 15 patients. These ADC maps were compared with conventional T2-weighted images. RESULTS Distinct subregions with different water diffusions were detected, even when the infarcted area appeared homogeneous on a T2-weighted image. The results also show that stroke lesions of the same age can have very different water diffusions. A trend towards an increasing diffusion coefficient in a lesion during the first several days following an acute event was observed in a group of patients imaged at multiple timepoints. CONCLUSION The measurement of diffusion coefficients in vivo now offers an opportunity for greater understanding of the biophysical changes that occur during the evolution of infarction in humans.