Cold Spring Harbor Perspectives in Medicine · 2012 · 58 citations · 152 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationVaccine ImmunologyVaccinologyAntiviral ImmunityHiv Vaccine DevelopmentImmunological Disease ModelsVaccinationViral InfectionsViral VaccinesExperimental Animal Models Of Viral InfectionHiv Infection ModelsImmunodeficiency Disease ModelsPrimate Infectious DiseasesTherapeutic Human Immunodeficiency Virus VaccinesTransgenic Nonhuman Primate ModelsVaccination Responses In ImmunodeficiencyVaccine Immunogen Design
Nonhuman primate (NHP) disease models for AIDS have made important contributions to the search for effective vaccines for AIDS. Viral diversity, persistence, capacity for immune evasion, and safety considerations have limited development of conventional approaches using killed or attenuated vaccines, necessitating the development of novel approaches. Here we highlight the knowledge gained and lessons learned in testing vaccine concepts in different virus/NHP host combinations.
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