Bioinformatics · 2001 · 18 citations · 8 references
Life SciencesBioinformaticsMicrobiologyComputational BiologyMicrobial Systems BiologyNetwork BiologyMolecular Interaction NetworksProtein-protein Interaction AnalysisProtein-protein Interaction NetworksBacillus SubtilisInteractive Graph VisualizationInteractomicsInterface DefinitionInteroperable Object ReferenceObject Request Broker ArchitectureProtein Interaction DatabasesProtein Interaction Network Visualization
MOTIVATION: Protein-protein interactions are a potential source of valuable clues in determining the functional role of as yet uncharacterized gene products in metabolic pathways. Graph-like structures emerging from the accumulation of interaction data make it difficult to maintain a consistent and global overview by hand. Bioinformatics tools are needed to perform this graph visualization while maintaining a link to the experimental data. RESULTS: "SPiD" is an online database for exploring networks of interacting proteins in Bacillus subtilis characterized by the two-hybrid system. Graphical displays of interaction networks are created dynamically as users interactively navigate through these networks. Third party applications can interface the database through a Common Object Request Broker Architecture (CORBA) tier. AVAILABILITY: SPiD is available through its web site at http://www-mig.versailles.inra.fr/bdsi/SPiD, and through an Interoperable Object Reference (IOR) and its associated Interface Definition Language (IDL). CONTACT: hoebeke@versailles.inra.fr
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A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Peter Uetz, Loïc Giot, Gerard Cagney et al. · Nature · 2000 · 4.7K citations
The protein–protein interaction map of Helicobacter pylori
Jean‐Christophe Rain, Luc Selig, Hilde De Reuse et al. · Nature · 2001 · 1.1K citations