Role of Spinal P2Y₆and P2Y₁₁Receptors in Neuropathic Pain in Rats: Possible Involvement of Glial Cells

Abstract

Our data suggest that spinal P2Y6 is present in spinal microglia while P2Y11 receptors are present in both spinal microglia and astrocytes, and both receptors are up-regulated in rats subjected to spinal nerve injury. In addition, our data suggest that the spinal P2Y6 and P2Y11 receptors participate in the maintenance of neuropathic pain.