Concepedia

Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells.

Zeynep Ocak, Muradiye Acar, Esra Gündüz, Mehmet Gündüz, Kadir Demircan, Ümmügül Üyetürk, Tevfik Özlü

PubMed · 2013 · 19 citations · 10 references

Abstract

The increase in ADAMTS9 expression can be a useful factor in the prevention of possible metastasis in breast cancer and for the occurrence of a tumor suppressive effect. Hypericin increases the expression of ADAMTS9, therefore, it may show its antitumoral and antiapoptotic effects by means of ADAMTS9.

References

10

Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma

Sarah Porter, Stuart D. Scott, Elaine M. Sassoon et al. · Clinical Cancer Research · 2004 · 244 citations

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

Dick Wågsäter, Hanna Björk, Chaoyong Zhu et al. · Atherosclerosis · 2007 · 122 citations

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Extracellular Protease <i>ADAMTS9</i> Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

Paulisally Hau Yi Lo, Hong Lok Lung, Arthur Kwok Leung Cheung et al. · Cancer Research · 2010 · 117 citations · Full text

<i>ADAMTS8</i> and <i>ADAMTS15</i> expression predicts survival in human breast carcinoma

Sarah Porter, Paul N. Span, Fred C.G.J. Sweep et al. · International Journal of Cancer · 2005 · 92 citations · Full text

Theoretical study of hypericin

Rita C. Guedes, Leif A. Eriksson · Journal of Photochemistry and Photobiology A Chemistry · 2005 · 80 citations

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