Breaking the Symmetry of Axially Chiral <i>N</i>‐Aryl‐2(1<i>H</i>)‐pyrimidinones by Spontaneous Crystallization

Abstract

No outside source of chirality was needed to resolve the racemate of an axially chiral pyrimidinone (see scheme). Crystallization at high temperatures gave optically active material in up to 73 % ee. The resolved product could be reduced with NaBH4 with high enantioselectivity.