Graphene Oxide–Peptide Conjugate as an Intracellular Protease Sensor for Caspase‐3 Activation Imaging in Live Cells

Abstract

All systems GO! An intracellular protease sensor is based on the covalent conjugate of graphene oxide and peptide substrates with fluorophore labels. The conjugate can be delivered into live cells and provides specific, high-contrast imaging of caspase-3 activation (see picture; orange=cell penetration peptide, blue/black=caspase-3 peptide probe). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.