Oxidation of Guanine and 8‐oxo‐7,8‐Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen‐18 Labeling Experiments

Abstract

Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O− from CO3.− to the end products (see scheme).