A Calixarene with Four Peptide Loops: An Antibody Mimic for Recognition of Protein Surfaces

Abstract

Four constrained cyclic peptides containing the sequence Gly-Asp-Gly-Asp are linked to a central calixarene scaffold (see diagram below) to form a large surface area for interaction with proteins. These antibody mimics not only bind strongly to the surface of cytochrome c but also disrupt its interaction with reducing agents.