AVE0118, Blocker of the Transient Outward Current ( <i>I</i> <sub>to</sub> ) and Ultrarapid Delayed Rectifier Current ( <i>I</i> <sub>Kur</sub> ), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat - Concepedia

Concepedia

Publication | Open Access

AVE0118, Blocker of the Transient Outward Current ( <i>I</i> <sub>to</sub> ) and Ultrarapid Delayed Rectifier Current ( <i>I</i> <sub>Kur</sub> ), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat

DOI Full Paper Access

76

Citations

36

References

2006

Year

Sunniva de Haan, Maura Greiser, Erik Harks, Yuri Blaauw, Arne van Hunnik, Sander Verheule, Maurits A. Allessie, Ulrich Schotten

Abstract

Conventional positive inotropic drugs showed limited effect on atrial contractility after cardioversion of AF or produced QT prolongation. In contrast, the I(to)/I(Kur) blocker AVE0118 fully restored atrial contraction without proarrhythmic effects on the ventricle.

References

	Year	Citations

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