Chiral 4‐Phenyl‐2‐trifluoromethyloxazolidine: A High‐Performance Chiral Auxiliary for the Alkylation of Amides

Abstract

A bit on the side: Extremely high diastereoselectivities (>99 % de) were attained in the α-alkylation and -allylation of amides by using a trifluoromethylated (sphere) oxazolidine as a chiral auxiliary. Reductive cleavage of the amide bond led to the recovery of this fluorinated chiral auxiliary in high yield. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600738_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.