Transformations of X (C, O, N)–CN bonds: cases of selective X (C, O, N)–C activation

Abstract

Activation of C–C, C–N, and C–O bonds has in recent decades been recognized as a valuable strategic objective. While considerable progress has been achieved, many of the more challenging issues, e.g., regioselective activation of specific C–X (C, O, N) bonds, chemoselective cleavage of C(sp3)–X bonds, enantioselective activation and even the successful application of solid catalysts in such transformations remain elusive. The research disclosed herein summarize recent advances in C–X bond cleavages, including regioselective processes, although the carbon is activated in the form of a cyano group. Activation and even the successful application of solid catalysts in such transformations remain elusive. The research disclosed herein summarize recent advances in C–X bond cleavages, including regioselective processes, although the carbon is activated in the form of a cyano group.