Concepedia

Clinical Evidence for Predominance of Delta-5 Steroid Production in Women with Polycystic Ovary Syndrome

M.A. Rosencrantz, Mickey S. Coffler, A. Haggan, Kimberly B. Duke, Michael Donohue, Rana F. Shayya, H. Irene Su, R. Jeffrey Chang

The Journal of Clinical Endocrinology & Metabolism · 2011 · 27 citations · 34 references

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Abstract

In PCOS women, maximal A and T responses to hCG relative to those of 17-OHP are consistent with ovarian androgen overproduction via the delta-5 pathway.

References

34

R: A Language and Environment for Statistical Computing

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A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

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Insulin Stimulates Androgen Accumulation in Incubations of Ovarian Stroma Obtained from Women with Hyperandrogenism*

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Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

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Augmented Androgen Production Is a Stable Steroidogenic Phenotype of Propagated Theca Cells from Polycystic Ovaries

Velen L. Nelson, Richard S. Legro, Jerome F. Strauss et al. · Molecular Endocrinology · 1999 · 530 citations · Full text

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