Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis

The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

Ferdinand C. Breedveld, Michael H. Weisman, Arthur F. Kavanaugh et al. · Arthritis & Rheumatism · 2005 · 1.8K citations

Medicine, Pharmacology, Pharmacotherapy +17

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

Lars Klareskog, Désirée van der Heijde, J Jäger et al. · The Lancet · 2004 · 1.8K citations

Medicine, Pharmacology, Pharmacotherapy +10

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

Joan M. Bathon, Richard W. Martin, Roy Fleischmann et al. · New England Journal of Medicine · 2000 · 1.8K citations · Full text

Medicine, Immunology, Pharmacology +12

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

Y P M Goekoop-Ruiterman, Jeska K de Vries‐Bouwstra, Cornelia F Allaart et al. · Arthritis & Rheumatism · 2005 · 1.5K citations · Full text

Medicine, Clinical Sciences, Pharmacotherapy +14

Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial

Catriona Grigor, Hilary A. Capell, A. Stirling et al. · The Lancet · 2004 · 1.4K citations

Medicine, Clinical Sciences, Internal Medicine +5