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Structure elucidation of a glycopeptide antibiotic, OA-7653
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1988
Year
Medicinal ChemistryAntimicrobial Drug DiscoveryBiochemistryNatural SciencesGlycobiologyMass SpectrometryNov. NishidaStructure ElucidationAntibacterial AgentAntimicrobial ChemotherapyMicrobiologyAntimicrobial CompoundCarbohydrate-protein InteractionChemical BiologyMedicinePeptide Cell WallAntimicrobial ResistanceGlycosylation
The structure of a vancomycin-type antibiotic, OA-7653, isolated from Streptomyces hygroscopicus subsp. hiwasaensis subsp. nov. Nishida, has been elucidated by a combination of classical chemical methods, mass spectrometry, and nuclear magnetic resonance spectroscopy. The interaction of OA-7653 with the peptide cell wall analogues N-acetyl-D-alanyl-D-alanine, and di-N-acetyl-L-lysyl-D-alanyl-D-alanine, in solution in aqueous dimethyl sulphoxide, has been examined by n.m.r. and u.v. difference spectroscopy.