Pediatric Critical Care Medicine · 2010 · 23 citations · 17 references
MedicineInfectious DiseasesPediatricsEmerging Infectious DiseasesImmunizationPediatric Infectious DiseasesOutbreak ResponsePandemic PreparednessPandemic ResponsePediatric EmergenciesVaccinationAttack RateInfectious Disease EmergenciesIntensive Care Unit OutbreaksPandemic DisruptionPediatric Intensive Care SurgePediatric VaccinationSocial Distancing BehaviorSocial Distancing Policy
OBJECTIVE: To investigate the possibility of pediatric intensive care unit shortfalls, using pandemic models for a range of attack rates and durations. The emergence of the swine origin pH1N1 virus has led to concerns about shortfalls in our ability to provide pediatric ventilation and critical care support. DESIGN: Modeling of pediatric intensive care demand based on pH1N1 predictions using simulation techniques. SETTING: Simulation laboratory. PATIENTS: None. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data collected during the first wave of the pH1N1 in children in Canada were applied to several second wave pandemic models to explore potential pediatric intensive care unit ventilatory demands for Canada and to investigate the impact of vaccination upon these demands. In almost all cases studied, even for relatively low attack rates of 15%, significant pediatric intensive care unit shortages would be expected to occur. Vaccination strategies targeting 50% of the population significantly reduced demand, but shortages may still be expected. Although shortfalls can occur in all provinces, Ontario and British Columbia may experience the greatest supply-demand difference, even at low attack rates. CONCLUSION: Reducing the attack rate among children, whether through vaccination or additional measures, such as social distancing, will be critical to ensure sufficient pediatric intensive care unit capacity for continued pediatric care.
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Joël Mossong, Niel Hens, Mark Jit et al. · PLoS Medicine · 2008 · 3.2K citations · Full text
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Veterinary Medicine, Infectious Disease Control, Infectious Diseases +16