Transactions of the Royal Society of Tropical Medicine and Hygiene · 2006 · 44 citations · 12 references
Veterinary MedicineInfectious DiseasesPharmacotherapyHepatologyInfectious Disease PathologyParasitologyHepatic NecrosisHepatic ParasitismImmunopathology Of Parasitic DiseaseLiver DiseaseParasitic Disease PathogenesisParasitic PathologyConfluent NecrosisDrug-induced Hepatocellular NecrosisHepatic Parasitic PathologyHepatic PathogenesisInfectious HepatitisIvermectin TreatmentLiver Biopsy HistopathologyParasitic Hepatopathology
Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.
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