Direct Asymmetric α‐Allylation of Aldehydes with Simple Allylic Alcohols Enabled by the Concerted Action of Three Different Catalysts

Abstract

Triple catalysis: The title reaction between α‐branched aldehydes and allylic alcohols, which generates all‐carbon quaternary stereogenic centers, constitutes the first asymmetric Tsuji–Trost‐type α‐allylation of carbonyl compounds with allylic alcohol (see scheme). This reaction is catalyzed by three different species, [Pd(PPh₃)₄], the chiral Brønsted acid TRIP, and benzhydryl amine.