Enantioselective pharmacokinetic–pharmacodynamic modelling of carvedilol in a<i>N</i>G-nitro-<scp>l</scp>-arginine methyl ester rat model of secondary hypertension

Abstract

Carvedilol showed enantioselective non-linear pharmacokinetic properties in both groups. An enhanced hypotensive activity of carvedilol was found in L-NAME hypertensive rats compared with control rats, which may be explained by the greater potency of carvedilol for sympathetic vascular tone inhibition.