Synthesis of functionalized furan derivatives by hydroxyalkylation of methyl 2-siloxycyclopropanecarboxylates

Abstract

A variety of methyl tetrahydrofuran-3-carboxylates (4) or the 5-oxo analogues (6) are available in good overall yield by deprotonation of cyclopropanes (1), addition of carbonyl compounds, ring cleavage, and reductive or oxidative work-up, respectively.