Caffeine Occupancy of Human Cerebral A₁Adenosine Receptors: In Vivo Quantification with¹⁸F-CPFPX and PET

Abstract

Given a biologic half-life of about 5 h, caffeine might therefore occupy up to 50% of the cerebral A(1)AR when caffeinated beverages are repeatedly consumed during a day. Furthermore, the present study provides evidence that (18)F-CPFPX PET is suitable for studying the cerebral actions of caffeine, the most popular neurostimulant worldwide.