Life SciencesImmunologyInfectious DiseasesImmunopathologyInflammationNeuroimmunologyAutoimmune DiseasesAutoimmune Hematologic DiseaseEncephalitisHematologic DisordersPediatric LymphomasImmune System DisruptionNeurological PathogenesisRituximab-based Therapy
Hemophagocytic lymphohistiocytosis (HLH) is one of the complications of Epstein-Barr virus (EBV) infection. Although the patients who have developed HLH following EBV have normal immune system, there are a few patients with EBV-induced immune deficiency who develop HLH as well. Here, we describe the case of a 10-year-old girl with neurological complications caused by EBV-induced HLH. The patient received rituximab, leading to weakening inflammation associated with EBV infection and suppression of disease through quick treatment.
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HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
Jan‐Inge Henter, AnnaCarin Horne, Maurizio Aricò et al. · Pediatric Blood & Cancer · 2006 · 5.3K citations
Medicine, Hematology, Immunology +17
Jong‐Ding Lay, C J Tsao, J Y Chen et al. · Journal of Clinical Investigation · 1997 · 237 citations · Full text
Life Sciences, Immunology, Pathology +16