An Oxidative Prins–Pinacol Tandem Process and its Application to the synthesis of (−)‐Platensimycin

Abstract

Center stage: An oxidative Prins–pinacol tandem process mediated by a hypervalent iodine reagent has been accomplished. The strategy allows rapid access to highly functionalized spirocyclic cores (see scheme) present in many natural products. A first application to the formal synthesis of (−)-platensimycin has been achieved.