Predominant formation of heavily pigmented dermal melanocytomas resembling ‘animal‐type’ melanomas in hepatocyte growth factor (C57BL/6 × C3H)F₁ mice following neonatal UV irradiation

Abstract

In contrast to HGF animals on an albino (FVB) background, HGF animals on the pigmented (C57BL/6 x C3H/HeN)F(1) background do not develop classic radial growth phase melanoma but rather predominantly develop dermal melanocytomas resembling the 'animal-type' melanoma occasionally seen in humans. These results demonstrate the influence of genetic background on histologic pattern of UV-induced melanomas in mice.