Immunization with Recombinant <i>Streptococcus pneumoniae</i> Neuraminidase NanA Protects Chinchillas against Nasopharyngeal Colonization

Abstract

Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.