Cancer Research · 2004 · 66 citations · 21 references
MedicineCancer BiologyOncologyBreast OncologyGene Expression AnalysisMolecular OncologyBreast PathologyCancer BiomarkersExpression Signature DiscoveryMolecular Classification Of TumorsMolecular Tumor ProfilingTumor MarkersBreast Cancer Molecular SubtypesBreast Cancer PrognosisBreast Tumor ClassificationExpression ProfilingMolecular Prognostic MarkersPrognostic Expression SignaturesPrognostic Gene SignaturesPrognostic Tumor Markers
The Nottingham prognostic index (NPI) is a widely used clinicopathological staging system for breast cancer prognostication. Using a step-wise classification approach where breast tumor expression profiles were first divided into general "molecular subtypes" [estrogen receptor (ER)+, ER-, ERBB2+], followed by an independent analysis of each subtype, we identified a 62-gene expression signature (NPI-ES) highly correlated to the NPI in ER+ tumors. The NPI-ES classified the majority of ER+ tumors into two distinct groups with high confidence and was significantly correlated to NPI status in two independent sets of ER+ tumors derived from different centers. The NPI-ES is comparable to the classical NPI in identifying patients likely to exhibit a poor clinical prognosis, as well as to a recently described "prognosis signature" for breast cancer. Our findings demonstrate how expression profiling can complement classical staging systems employing histopathological parameters scored over a continuous range of values.
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Molecular portraits of human breast tumours
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